CIDRAP Antimicrobial Stewardship Project Newsletter – Oct 22, 2020
In this week's issue:
- What's new at CIDRAP-ASP
- Webinars on pediatric antibiotic prescribing and development
- AMR communication during COVID-19
- Drug-resistant TB prevention and treatment during the pandemic
- Stewardship principles in critical care during COVID-19
- Gonorrhea antibiotic clinical trials during the pandemic
- AMR, antibiotic use, and COVID-19 in Bangladesh
- Antibiotic use reporting for raw meat in San Francisco
- Team antibiotic review form for rotating pharmacy students
- Sustainability of stewardship in a Canadian ICU
WHAT'S NEW AT CIDRAP-ASP?
[Register] With support from an educational grant from bioMérieux, CIDRAP-ASP is pleased to host a free Nov 4 webinar on "Diagnostics and Antimicrobial Stewardship: How Can We Elevate?," during which CIDRAP-ASP outreach coordinator Marnie Peterson, PharmD, PhD, will moderate a discussion among Dilip Nathwani, OBE, MBChB, and Philipp Schuetz, MD, MPH.
[Engage] The Antimicrobial Resistance (AMR) Fighter Coalition—in partnership with CIDRAP, the American Society for Microbiology, Wellcome, the Surveillance and Epidemiology of Drug-resistant Infections Consortium, and the US Centers for Disease Control and Prevention—is hosting a webinar series on "AMR in the Light of COVID-19." The next webinar is on Nov 5 and will center on the theme "Aiming in the dark: what happens when disease spreads without diagnosis," with presentations from Catharina Boehme, MD, Erin Jorgensen, PhD, Robin Patel, MD, and Amadou Alpha Sall, PhD. Manica Balasegaram, BM BS, MSc, will moderate the conversation.
[Connect] Have you visited our ASP Diagnostics page recently for information on antibiogram development and susceptibility testing, biomarker use, rapid and point-of-care diagnostics, therapeutic guidance, and considerations for laboratory and diagnostic capacity in low- and middle-income countries? New resources are added at least weekly.
[Read] CIDRAP News recently published an interview with John Rex, MD, about the US PASTEUR (Pioneering Antimicrobial Subscriptions to End Upsurging Resistance) Act and much more.
[Research] Please take a moment to visit our recently launched resource hub on COVID-19 and antimicrobial stewardship, our compendium of databases and tools for AMR surveillance, our antimicrobial stewardship diagnostics resources, our database containing hundreds of publicly available clinical tools for antimicrobial stewardship programs, and our educational multimedia page. The surveillance and diagnostics pages are updated at least weekly, and we add new educational tools monthly.
[Stay Current] If you'd like to stay current on all our news and events, please follow CIDRAP-ASP on Twitter and Facebook, subscribe to our YouTube channel, and subscribe to our antimicrobial stewardship podcasts on iTunes or Spotify.
GLOBAL ANTIMICROBIAL STEWARDSHIP NEWS, EVENTS, AND RESEARCH
[Register] On Oct 28, the Global Antibiotic Research & Development Partnership (GARDP) will host a webinar on "Developing antibiotics for children—medical need and regulatory challenges," featuring presentations from Phoebe Williams, MBBS, DPhil, MSc, and Irja Lutsar, MD, PhD. Sally Ellis, MSc, will moderate the discussion. And in a Nov 10 Benioff Children's Hospital Oakland Antibiotic Awareness Week Grand Rounds, Rachel Wattier, MD, MHS, and Prachi Singh, DO, will discuss "What You Need to Know about Antibiotic Prescribing in a Pandemic."
[Engage] In the Financial Times, Clive Cookson describes a collaboration between the Financial Times and Wellcome Trust to hold a workshop that looked at the challenges in communicating about AMR during and beyond the COVID-19 pandemic, followed by development of a video for the public that highlights the problem of AMR and possible solutions.
[View] An archived webcast and PDF presentations from the 2-day virtual Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria (PACCARB) meeting on "AMR and COVID-19" are available to view and download.
[Explore] The TB Alliance highlights challenges to tuberculosis prevention, healthcare access, and appropriate treatment for drug-resistant infections during the COVID-19 pandemic, noting the need for greater resource allocation, prioritized short all-oral therapies, and full funding of a portfolio of treatments, vaccines, and diagnostics.
[Assess] On The Hill, Chia-Yi Hou, PhD, MA, describes possible contributors to AMR during the COVID-19 pandemic, highlighting work on phage therapy, diagnostics development and training, biomarker use, racial disparities in antibiotic use, and resource allocation.
[Study] In Intensive Care Medicine, Jan J. De Waele, MD, PhD, et al describes the struggle to maintain antimicrobial stewardship principles in the intensive care unit during the COVID-19 pandemic, recommending steps toward rational infection management, guidance on empirical antibiotic therapy, and a reminder that stewardship is in line with patient well-being in critical care settings.
[Rethink] In a viewpoint for the GARDP REVIVE website, Markus Heep, MD, Esther Bettiol, MD, PhD, Tanyaporn Wansom, MD, PhD, MPP, and Hilary Johnstone, MBChB, MSc, discuss the process of running a phase 3 trial for zoliflodacin for gonorrhea across the Netherlands, South Africa, Thailand, and the US during the COVID-19 pandemic.
[Discover] In a medRxiv preprint, Monira Parveen, MD, MBBS, et al provides an overview of AMR and inappropriate antibiotic use in Bangladesh during the COVID-19 pandemic, highlighting potential mitigation strategies that include restrictions on over-the-counter antimicrobial sales, biomarker testing, provider and patient education, and the effective use of telemedicine.
[Examine] The San Francisco Department of the Environment published a report on the city's 2017 ordinance that requires retailers of raw meat to report antibiotic use, finding that, in 2019, chicken and turkey products continued to have the highest level of reporting transparency, with 40% of chicken and 74% of turkey products including antibiotic use data, in comparison with 2% of beef, 2% of pork, and 14% of lamb products.
[Learn] In Pharmacy, Kimberly E. Ng, PharmD, and Nicole Bradley, PharmD, describe the use of a team antibiotic review form (TARF) among 26 pharmacy students on rotation, finding that, after 889 interventions, all pharmacy students said that the TARF increased their knowledge on how to evaluate antibiotics.
[Analyze] In a commentary for United Hospital Fund, Pooja Kothari, RN, MPH, discusses uncertainty about the need for antibiotic prescribing during the COVID-19 pandemic, highlighting evidence-informed practices that may address the issue from an administrative or educational standpoint.
[Review] In Critical Care Medicine, Prateek Sehgal MD, et al assess the work of an antimicrobial stewardship program in a Canadian intensive care unit from June 2010 to September 2019, finding that acceptance of suggestions to alter antibiotic therapy remained stable at 67% throughout the decade, with lower acceptance levels associated with admission to burn surgery; pneumonia treatment; unknown source of infection; and suggestions related to spectrum, formulation, or agent. The authors say that the findings support the need for sustained audit and feedback with greater attention to interventions that target specialized care, therapy in the absence of pathogen confirmation, and nephrotoxicity.
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