GI Problems | Whole-Body Effects of Cancer | Potential Drug Targets

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Cancer Information Highlights From the National Cancer Institute Updating you about cancer causes, prevention, screening, treatment, coping, and more   Constipation and Cancer Treatment   If you've been treated for cancer, you may be familiar with a common side effect: constipation. This new page explains symptoms of constipation, what causes it, ways to prevent it, and how to treat it. Read More Diarrhea and Cancer Treatment   Diarrhea is another unfortunate side effect of certain cancers and cancer treatments. Learn about the causes of diarrhea, symptoms it may cause, ways to manage it, and how to talk with your doctor. Read More Bowel Obstruction and Cancer Treatment   A bowel obstruction is a serious problem that can be caused by cancer or cancer treatment. Learn more about bowel obstruction, such as what causes it, symptoms to look for, and how it is treated on this new page. Read More Approaching Cancer as a Disease That Affects the Entire Body   The whole-body effects of cancer can decrease a person's quality of life and allow tumors to spread to different parts of the body. The NCI Fiscal Year 2026 Annual Plan and Professional Judgment Budget Proposal explains how more investments are needed to unite various research areas for a clearer picture of how cancer communicates with and affects healthy organs and tissues. Read More Trial Supports Uninterrupted Use of Imatinib for GIST Study results showed that people with gastrointestinal stromal tumors (GISTs) who stopped imatinib (Gleevec) had a more rapid worsening of disease, a shorter time until resistance, and did not live as long as people who continued the therapy uninterrupted. Read More Study Finds Hundreds of Potential Targets for Cancer Drugs   Using detailed information on genes and proteins from more than 1,000 tumors representing 10 cancer types, researchers have found hundreds of promising targets for existing drugs or possible new cancer drugs. Read More New FDA Approval for Mesothelioma The Food and Drug Administration (FDA) approval for pembrolizumab (Keytruda) now includes malignant pleural mesothelioma. Pembrolizumab is used with chemotherapy when the cancer has spread or cannot be removed by surgery. Read More   Contact Us   Information specialists at NCI's Cancer Information Service (CIS), NCI's contact center, are available to help answer your cancer-related questions in English and Spanish. This page tells you how to reach us by phone, chat, or email.

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