Tuesday, November 10, 2020

New Research Spotlight: Gene Regulation May Influence Racial Disparities in Breast Cancer Survival

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NIMHD-Funded Study Reveals Gene Regulation May Influence Racial Disparities in Breast Cancer Survival


Asian Female doctor discussing medical results on iPad with Black Female patient

In the United States, African American women are more likely than European American women to die from breast cancer. The survival gap is widest among women with breast cancer that is associated with receptors for hormones causing uncontrolled growth of breast cells. Researchers have found that genetic markers expressed in breast tissue could potentially be used to predict breast cancer survival based on race.

A study recently published in Clinical Cancer Research reveals that factors in the genetic pathway of breast tissue might play a role in the worse survival outcomes for African American than European American women with breast cancer. Survival may depend on other factors, such as access to and quality of care, but the results of this study highlight genetic markers that clinicians could use to predict breast cancer survival based on race. The study also indicates potential targets for therapy and promotes further investigation to understand the biological processes that may influence racial disparities in breast cancer survival.

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