Wednesday, June 29, 2022

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A revolutionary technology turns 10 years old...
June 29, 2022 View Online | Sign Up | Shop

Morning Brew

Fidelity

Good morning. Morning Brew Store is holding our first-ever major sale ahead of the Fourth of July. Celebrate the red, white, and Brew (sorry) with everything from corporate humor tees to Money with Katie merch to golf polos. 30% off select styles, for a limited time only.

Start browsing here.

Jamie Wilde, Max Knoblauch, Neal Freyman

MARKETS

Nasdaq

11,181.54

S&P

3,821.55

Dow

30,946.99

10-Year

3.180%

Bitcoin

$20,373.10

AMD

$80.78

*Stock data as of market close, cryptocurrency data as of 8:00pm ET. Here's what these numbers mean.

  • Markets: Stocks sagged for the second straight day, with chip stocks taking some of the biggest blows. A new consumer report showed that Americans are not confident in the economy, but are confident that inflation will be sticking around for the next year.
  • Government: In explosive testimony before the Jan. 6 committee, Cassidy Hutchinson, a former top aide to former White House Chief of Staff Mark Meadows, described how then-President Trump knew that his supporters at the Jan. 6 rally were armed, but demanded that officials allow them to march to the Capitol anyway because they're "not here to hurt me."

SCIENCE

10 years of CRISPR

A DNA strand being cut Dianna "Mick" McDougall, Photos: Getty Images

This week marks one decade since CRISPR made its public debut in an academic paper named, "A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity." Which is like if Alice in Wonderland was named Girl Takes a Nap.

CRISPR allows scientists to reliably edit the DNA of plants, animals, and humans, snipping out and repairing genetic sequences. When its creators, Jennifer Doudna and Emmanuelle Charpentier, won the Nobel Prize for Chemistry in 2020, the award committee called it "an epoch-making experiment."

Real-world applications for CRISPR are developing remarkably fast by science-world standards. Here are some innovations that make us feel like we're living in the year 3000:

  • A treatment for the blood disorders sickle cell disease and beta thalassemia could be approved this year. Patients are already receiving the experimental one-time treatment, and it's working.
  • Produce modified to contain more vitamins or the ability to survive drought or diseases (like a tomato that accumulates Vitamin D when under sunlight) could land on grocery shelves within a few years.
  • Researchers are even using CRISPR to learn more about our Neanderthal and ape great-to-the-zillionth-exponent grandparents.

But the future isn't full speed ahead

One major issue dogging CRISPR: affordability. The treatment for sickle cell disease is complex and costs up to $2 million for one patient. Doudna told STAT News that she's working on a way to have CRISPR do its gene-editing "in vivo" (in the body) instead of in the lab, making the process simpler and cheaper.

Another speed bump for CRISPR: ethics questions around editing the genes of human embryos. A doctor in Shenzhen, China, was sentenced to prison in 2019, one year after he modified and reimplanted three embryos into patients. The gene he edited was intended to make the children more HIV resistant, but some worry embryo editing could go beyond disease prevention to tweaking babies' height, eye color, or even intelligence. "Playing God," if you will.

Looking ahead…within our lifetimes, CRISPR could be used to treat or even cure disorders ranging from heart disease to cancer—not to mention its vast nonmedical applications, which include reviving woolly mammoths.—JW

        

TOGETHER WITH FIDELITY

Open up your portfolio and say "ahhhhhhh"

Fidelity

We're all trying to make healthier, more responsible choices, from opting for reusable over plastic to drinking 8 glasses of water per day (help, it's so much water!).

But what if your portfolio *also* reflected your commitment to healthy living—from fitness and self-care to mindfulness and sustainability?

Meet the Fidelity Healthy Future Fund (FAPHX). This fund lets you invest in companies that align with your health and wellness priorities. Fidelity uses its active management expertise to research and identify companies with goals to:

  • improve or extend life expectancy
  • enhance health and well-being in people's lives
  • reduce environmental impact

Invest in the things that help you live healthier with Fidelity's Healthy Future Fund. Learn more here.

WORLD

Tour de headlines

Ghislaine Maxwell and Jeffrey Epstein on a private plane Ghislaine Maxwell and Jeffrey Epstein on a private plane. US Attorney's Office SDNY.

Ghislaine Maxwell gets 20 years in prison. The former British socialite was sentenced to two decades in US prison yesterday for helping Jeffrey Epstein, her then-boyfriend, sexually abuse young girls from 1994–2004. "It is important to emphasize that although Epstein was central to this criminal scheme, Ms. Maxwell is not being punished in place of Epstein or as a proxy for Epstein," Judge Alison Nathan said. Epstein died by suicide in jail in 2019.

Airbnb makes its party ban permanent. The home rental company is etching its ban on "disruptive parties and events" in stone, citing a 44% annual drop in reports of parties at its listings since the policy was implemented. Airbnb first banned open-invite parties in response to a shooting that killed five at a party in 2019, then temporarily banned all parties and events during the first Covid summer in August 2020. It's relaxing some policies, though: A 16-person occupancy cap at large listings is being lifted.

NATO poised to welcome two new members. Sweden's and Finland's bids to join the security alliance took a big step forward yesterday when Turkey gave them its blessing. By adding the two Nordic countries to its club, NATO would more than double the length of its border with Russia, the global power it was formed to counteract. In response to Russia's invasion of Ukraine, NATO has launched its biggest mobilization since the end of the Cold War, per the WSJ.

GOVERNMENT

It seems the auditor has become the auditee

Tim Robinson saying I Think You Should Leave/Netflix via Giphy

Ernst and Young (EY), one of the world's largest auditing firms, has agreed to pay a $100 million SEC fine after admitting hundreds of its accountants have cheated on their ethics exams between 2017 and 2021. Okay, but did someone tell them that cheating wasn't allowed?

Some necessary perspective: The role of audit firms like EY is to hold companies accountable for their financial reporting, so ethics and integrity should be a chief concern.

But, according to the SEC, from 2017 to 2021, dozens of the firm's employees cheated on the ethics portion of an exam required to become a certified public accountant (CPA), and hundreds more reportedly cheated on tests that keep the certification up to date. In addition, internal investigations at EY uncovered the cheating, but the firm didn't disclose them to the SEC for nine months. The cruel irony? Had they studied for the ethics test, they would have known this was bad.

The fine is the largest that the SEC has ever levied against an auditing firm, due to EY's decision to mislead investigators. It's twice the amount imposed on another "Big Four" accounting firm, KPMG, after a similar cheating scandal was uncovered at that company in 2019.—MK

        

SOCIAL MEDIA

Facebook and Insta scrub abortion pill posts

Mopping the floor in the Simpsons The Simpsons/Fox via Giphy

Following the Supreme Court's decision on Friday to overturn Roe v. Wade, mentions of abortion pills on social media platforms spiked. Facebook and Instagram, reports show, have been removing some of those posts minutes after they are published.

Reporters at Vice and the Associated Press posted about mailing abortion pills on Facebook since the ruling, and sure enough, those posts were removed. In the AP's case, the account was given a warning for violating company policy on "guns, animals and other regulated goods." But when the reporter swapped out the words "abortion pills" for "a gun" or "weed" Facebook did not touch those posts.

In response, Meta spokesperson Andy Stone tweeted that the company does not allow "content that attempts to buy, sell, trade, gift, request or donate pharmaceuticals," but acknowledged that it found "some instances of incorrect enforcement."

Big picture: Abortion pills, which account for more than half of abortions, are considered to be the next front in the legal battle over abortion access. The DOJ has said that the pills cannot be banned because they are an FDA-approved treatment, but several GOP-led states have already moved to block residents from obtaining them by mail.

Elsewhere in Roe news…

  • A Texas judge temporarily blocked the state's law banning all abortions following a lawsuit from pro-abortion rights groups. They're now allowed up to six weeks of pregnancy.
  • Retailers including Amazon, CVS, and Rite Aid have placed limits on purchases of emergency contraceptives, citing a surge in demand.—NF
        

GRAB BAG

Key performance indicators

A Rocket Lab rocket Rocket Lab

Stat: NASA launched a spacecraft roughly the size of your microwave yesterday, but the small vehicle has big ambitions. It's testing out a new orbital path around the moon—and, if that orbit works out, it could be used for a planned space station to be called Gateway that circles the moon. Gateway will be used as a launching pad for astronauts to make trips to the lunar surface.

Quote: "There is no magic bullet, but if there is something we can do, we will find it and we will do it."

Xavier Becerra, the secretary of health and human services, outlined several steps the Biden administration will take following the overturn of Roe v. Wade, such as increasing access to abortion pills, but also acknowledged his hands were mostly tied. The White House has been criticized by progressive Democrats for not doing more for reproductive rights following the SCOTUS decision.

Read: Why beauty matters, and how it has been destroyed by "usability." (The Cultural Tutor)

TOGETHER WITH STATE OF MATTER

State of Matter

Plastic bottles + oyster shells = the perfect Polo. Breathable, sweat wicking, sustainably made, and insanely comfortable, State of Matter Polos have it all. Each one is crafted from recycled plastic bottles and offers anti-odor protection, thanks to an all-natural treatment made with crushed oyster shells. Oh, and their 4th of July sale (read: 40% off sitewide) starts today.

WHAT ELSE IS BREWING

  • Pinterest CEO Ben Silbermann, who is also the company's co-founder, is stepping down and being replaced by Google's president of commerce Bill Ready.
  • China reduced its Covid quarantine requirements for inbound travelers by half, and Shanghai Disneyland said it will reopen tomorrow.
  • The growth in US home prices cooled in April for the first time since November of last year.
  • US health officials ramped up their fight against the monkeypox outbreak, expanding the group eligible to get vaccines and deploying more doses and testing capabilities.
  • Sri Lanka, which is in the midst of a severe economic crisis, blocked sales of fuel for nonessential services, shut down schools in cities, and told people to work from home in order to conserve depleted energy supplies.

BREW'S BETS

Apple's glow up: Here's the evolution of its macOS operating system, from 1984–present.

Earth.fm: It's like Spotify, but for natural soundscapes. Give it a listen.

It's time to build: Next time you're feeling lazy, watch this video and it might give you a push to get off the couch.

Set yourself apart: Take on the gnarly finance problems everyone else avoids, learn how to lead from current biz execs, or tap into your personal board of directors—it's all possible with Learning @ Morning Brew's Fall Accelerators, now taking applications.

GAMES

The puzzle section

Picdoku: Want a 2pm treat without the 4pm crash? Play today's cupcake-themed picdoku.

iPhone trivia

The iPhone turns 15 years old today, and we'll never pass up an opportunity for iPhone trivia. We'll give you the name of an iPhone model, and you have to determine whether it ever existed or if we just made it up. Here we go…

  1. iPhone 3G
  2. iPhone 4 Plus
  3. iPhone 5c
  4. iPhone 9
  5. iPhone XR
  6. iPhone 11 Pro Max

Check out more from the Brew

Interested in learning how Ray Dalio built the world's largest hedge fund from his apartment? Listen to or watch the latest Imposters episode.

We set out to find the next great startup. Are you buying into Beyond, the latest e-bike subscription service? Watch now.

Free first-class seats are 100% possible, and Money With Katie explains how in her free Travel Rewards email series. Check it out.

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ANSWER

  1. Real
  2. Fake
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  5. Real
  6. Real

✢ A Note From Fidelity

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Investing involves risk, including risk of loss.

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Written by Neal Freyman, Jamie Wilde, and Max Knoblauch

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