Tuesday, November 29, 2022

⚽️ Axios PM: USA's knockout foe

Plus: Rail reprieve | Tuesday, November 29, 2022
 
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Axios PM
By Mike Allen · Nov 29, 2022

Good afternoon: Today's PM — edited by Justin Green — is 478 words, a 2-minute read.

🚨Bulletin: Senate Minority Leader Mitch McConnell (R-Ky.) said anyone who meets with antisemites or white supremacists is "highly unlikely to ever be elected president of the United States."

  • Former President Trump dined last week with white nationalist Nick Fuentes.
 
 
1 big thing: Complications for Alzheimer's hope

Illustration: Shoshana Gordon/Axios

 

Patient deaths linked to lecanemab, a new Alzheimer's treatment, may complicate the drug's chances of hitting the market, Axios' Oriana Gonzalez and Caitlin Owens report.

Zoom out: Lecanemab offered renewed hope for an effective treatment for the disease when Phase III trials slowed the progression of Alzheimer's disease by 27%, per a press release.

  • Japanese drugmaker Eisai and its partner Biogen are releasing their late-stage clinical trial results tonight at the Clinical Trials on Alzheimer's Disease conference in San Francisco.

But a woman who was enrolled in a clinical trial for the drug died from a brain hemorrhage that researchers linked to the experimental treatment, Science reported Sunday.

  • It was the second death reported among patients in the clinical trial.

The bottom line: "If lots of people [on lecanemab] who go into the hospital with garden-variety strokes end up dying, that sets the field back decades," University of Kentucky neuroscientist Donna Wilcock told Science.

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⚽️ 2. U.S. advances
Team USA midfielder Weston McKennie celebrates the goal that put them into the knockout stage at the World Cup in Qatar. Photo: Patrick T. Fallon/AFP via Getty Images

The U.S. beat Iran 1-0 today to finish second in Group B behind England.

  • Team USA will play Team Netherlands on Saturday.

⚡️ Christian Pulisic, who scored the winning goal, was taken to a hospital for an abdominal injury, according to the U.S. Soccer Federation.

Go deeper.

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3. Catch up quick
Map showing the areas at risk for a severe weather outbreak. Map: NOAA/FEMA
  1. A significant outbreak of severe thunderstorms is unfolding across the South into tonight, Axios' Andrew Freedman reports.
  2. Between 400 and 500 migrant workers died ahead of this year's World Cup, a Qatari official told Piers Morgan. Go deeper.
  3. Houston lifted its boil water advisory. Go deeper.
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4. 🚂 Rail reprieve
This sign was installed at the White House today. Photo: Kent Nishimura/Los Angeles Times via Getty Images

In the face of a shutdown threatened for next week, President Biden reached the limits of his pro-labor stance, Axios' Emily Peck and Erin Doherty report.

At Biden's urging, Congress will take up legislation — expected to pass — forcing freight-railway workers to accept a union contract many don't like in order to avoid a strike that could have cost $2 billion a day.

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🎶 5. Top tunes of '22

Illustration: Sarah Grillo/Axios

 

Apple Music came out ahead of Spotify Wrapped this holiday season, Axios' Herb Scribner reports.

  • "Stay" by The Kid Laroi and Justin Bieber is the platform's top global song of the year.
  • Bad Bunny — who secured Apple Music's 2022 Artist of the Year award — became the first Latin artist to have the biggest album of the year on the platform.

Other top songs from Apple Music's global chart included:

  • "As It Was" by Harry Styles
  • "Wait For U" by Future featuring Drake and Tems
  • "Super Gremlin" by Kodak Black
  • "Easy on Me" by Adele
  • "Heat Waves" by Glass Animals

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Thanks to Sheryl Miller for copy editing today's PM.

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