Plus: Rail reprieve | Tuesday, November 29, 2022
| | | | | | | Presented By Instagram | | | | Axios PM | | By Mike Allen · Nov 29, 2022 | | Good afternoon: Today's PM — edited by Justin Green — is 478 words, a 2-minute read. 🚨Bulletin: Senate Minority Leader Mitch McConnell (R-Ky.) said anyone who meets with antisemites or white supremacists is "highly unlikely to ever be elected president of the United States." - Former President Trump dined last week with white nationalist Nick Fuentes.
| | | | | | 1 big thing: Complications for Alzheimer's hope |  | | | Illustration: Shoshana Gordon/Axios | | | | Patient deaths linked to lecanemab, a new Alzheimer's treatment, may complicate the drug's chances of hitting the market, Axios' Oriana Gonzalez and Caitlin Owens report. Zoom out: Lecanemab offered renewed hope for an effective treatment for the disease when Phase III trials slowed the progression of Alzheimer's disease by 27%, per a press release. - Japanese drugmaker Eisai and its partner Biogen are releasing their late-stage clinical trial results tonight at the Clinical Trials on Alzheimer's Disease conference in San Francisco.
But a woman who was enrolled in a clinical trial for the drug died from a brain hemorrhage that researchers linked to the experimental treatment, Science reported Sunday. - It was the second death reported among patients in the clinical trial.
The bottom line: "If lots of people [on lecanemab] who go into the hospital with garden-variety strokes end up dying, that sets the field back decades," University of Kentucky neuroscientist Donna Wilcock told Science. |     | | | | | | ⚽️ 2. U.S. advances | | Team USA midfielder Weston McKennie celebrates the goal that put them into the knockout stage at the World Cup in Qatar. Photo: Patrick T. Fallon/AFP via Getty Images The U.S. beat Iran 1-0 today to finish second in Group B behind England. - Team USA will play Team Netherlands on Saturday.
⚡️ Christian Pulisic, who scored the winning goal, was taken to a hospital for an abdominal injury, according to the U.S. Soccer Federation. Go deeper. | | | | | | | | A message from Instagram | | Explore 30+ Instagram tools helping teens have positive experiences | | |  | | | | Instagram's tools can help parents keep their teens safe on social media, help teens see less sensitive content and help them spend less time on our platform. Because teens' experiences on Instagram should be positive and supportive. Explore our tools and set them up today. | | | | | | 3. Catch up quick | | Map showing the areas at risk for a severe weather outbreak. Map: NOAA/FEMA - A significant outbreak of severe thunderstorms is unfolding across the South into tonight, Axios' Andrew Freedman reports.
- Between 400 and 500 migrant workers died ahead of this year's World Cup, a Qatari official told Piers Morgan. Go deeper.
- Houston lifted its boil water advisory. Go deeper.
| | | | | | | | 4. 🚂 Rail reprieve | | This sign was installed at the White House today. Photo: Kent Nishimura/Los Angeles Times via Getty Images In the face of a shutdown threatened for next week, President Biden reached the limits of his pro-labor stance, Axios' Emily Peck and Erin Doherty report. At Biden's urging, Congress will take up legislation — expected to pass — forcing freight-railway workers to accept a union contract many don't like in order to avoid a strike that could have cost $2 billion a day. | | | | | | | | 🎶 5. Top tunes of '22 |  | | | Illustration: Sarah Grillo/Axios | | | | Apple Music came out ahead of Spotify Wrapped this holiday season, Axios' Herb Scribner reports. - "Stay" by The Kid Laroi and Justin Bieber is the platform's top global song of the year.
- Bad Bunny — who secured Apple Music's 2022 Artist of the Year award — became the first Latin artist to have the biggest album of the year on the platform.
Other top songs from Apple Music's global chart included: - "As It Was" by Harry Styles
- "Wait For U" by Future featuring Drake and Tems
- "Super Gremlin" by Kodak Black
- "Easy on Me" by Adele
- "Heat Waves" by Glass Animals
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