In this issue:  Drawing on findings from the Oral Health in America report, NIDCR Director Rena D'Souza, DDS, PhD, and editors of the report have authored a series of perspective papers and accompanying editorials to propose strategies for addressing the nation's oral health challenges. The papers offer recommendations focusing on changes needed in dental health care, education, research, and policy to adapt to a changing oral health landscape that includes an older and more diverse population. |  In a webinar on May 10 attended by nearly 400 participants, NIDCR Deputy Director Jennifer Webster-Cyriaque, DDS, PhD; Division of Extramural Research Director Lillian Shum, PhD; and Division of Extramural Activities Director Lynn King, PhD, discussed NIDCR's strategic priorities through the lens of the Oral Health in America report, providing an overview of the institute's ongoing and upcoming research and training opportunities. A recording of this free online event is available on NIDCR's YouTube channel. |  Dr. D'Souza and Rebecca Baker, PhD, the director of the NIH Helping to End Addiction Long-term (HEAL) initiative, discussed NIDCR's HEAL-related efforts to find new, non-addictive treatments for orofacial pain. Dr. D'Souza also discussed the role dentists can play in helping to combat opioid addiction, as well as the oral health consequences of overuse of opioids and other substances. |  NIDCR joined NIH's Office of Equity, Diversity, and Inclusion in kicking off 2022 Asian American, Native Hawaiian, and Pacific Islander (AANHPI) Heritage Month in May with a virtual conversation with Asian American actor Utkarsh Ambdukar. Along with his mother, NIDCR researcher Indu Ambudkar, PhD, MSc, he discussed his experience growing up in a STEM-focused family and diversity in Hollywood. NIDCR Director Dr. D'Souza provided opening remarks for the event. | NIDCR Plans for 75th Anniversary in 2023  An NIDCR steering committee has begun discussing plans to commemorate the institute's 75th anniversary. Under consideration are various scientific symposia and seminars, including a training and career development symposium featuring current and past trainees. In 1948, President Harry S. Truman signed the bill establishing the National Institute of Dental Research. That name was amended in 1998 to include "Craniofacial" to better reflect the breadth of the institute's research. |
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 NIH Acting Director Lawrence A. Tabak, DDS, PhD, and several NIH institute directors appeared before the House Appropriations Subcommittee on Labor, HHS, Education, and Related Agencies on May 11 and the Senate Appropriations Subcommittee on Labor, HHS, Education, and Related Agencies on May 17 to discuss the fiscal year 2023 NIH budget request. The proposed budget will support science that helps tackle national health challenges, including health disparities, the rise of addiction, nutrition science, as well as operationalize the Advanced Research Projects Agency for Health—a new agency to drive transformational, high-risk research. |  The National Institute on Alcohol Abuse and Alcoholism launched the Healthcare Professional's Core Resource on Alcohol, which serves as a one-stop center for information and resources to help health care professionals provide evidence-based care for patients affected by alcohol problems. The resource provides the opportunity to earn free continuing medical education and continuing education credits. |  From understanding the biological and socioeconomic factors underlying pain and opioid use disorder to implementing safe and effective therapies for the conditions, the HEAL initiative details its research progress in its recently released 2022 annual report. NIDCR participates in this initiative, which also highlights novel technologies for interventions, the need to address health inequities, and connecting with individuals and communities affected by pain and opioid misuse. |  Nearly 100,000 highly diverse whole genome sequences, each providing information about almost all of an individual's genetic makeup, are now available to researchers through NIH's All of Us Research Program. About 50% of the data is from participants who identify with racial or ethnic groups that have historically been underrepresented in research. The data could enable researchers to address questions about health and disease and advance discoveries to reduce health disparities. |  In a recent perspective published in The Journal of Infectious Diseases, leaders from the National Institute of Allergy and Infectious Diseases write that achieving classical herd immunity against SARS-CoV-2 may not be attainable. However, controlling COVID-19 without major disruptions to society is now achievable because of immunity via prior infection or vaccination, drugs and therapies for COVID-19, and diagnostic tests. Research to develop a pan-coronavirus vaccine remains crucial. |  HHS Secretary Xavier Becerra, JD, announced the formal establishment of the Advanced Research Projects Agency for Health (ARPA-H) and appointed Adam H. Russell, DPhil, as acting deputy director. Russell currently serves as the chief scientist at the University of Maryland's Applied Research Laboratory for Intelligence and Security. He begins his new role in June as President Biden searches for an inaugural director. |  Norman Sharpless, MD, stepped down in April as the director of the National Cancer Institute (NCI), a position he held since 2017. During his leadership, Sharpless championed health equity by developing the Childhood Cancer Data Initiative and advocating for policies to support diversity in the cancer research workforce. NCI principal deputy director Douglas Lowy, MD, is serving as acting director until a permanent director is appointed by President Biden. | Back to top  A research team led by NIDCR researcher Eva Mezey, MD, PhD, found that the outer surfaces of axons—electrical signal-transmitting nerve cell fibers—are studded with protein "entry factors" used by the SARS-CoV-2 virus to invade cells. The findings point to the possibility that the virus could infect taste-sensing nerves and may explain the taste loss that affects about 39% of those who have COVID-19. |  Using imaging techniques to visualize pain signals in facial nerves, NIDCR researchers Ashok Kulkarni, PhD, Kenneth Yamada, MD, PhD, and colleagues identified a protein called Cdk5 that enhances neurons' responses to painful stimuli. Blocking the protein in mice blunted pain signaling, suggesting the results could inform the development of safer, more effective, non-opioid pain therapies. |  Certain gut bacteria trigger an immune response that prompts loss of tooth-supporting bone in mice, akin to the type of bone loss that can result from periodontal disease, according to a recent NIDCR-funded study. The findings challenge previous notions that bone loss in the mouth is regulated solely by oral microbes and point to a role for gut microbes in oral health, suggesting treatments that modulate gut bacteria may support oral bone health. |  Recent NIDCR-funded research found that expanding public coverage of dental care was linked to reduced racial and ethnic disparities in the use of dental services. However, despite lessened disparities, overall use of dental care remained low across racial and ethnic groups, indicating that insurance coverage is one of multiple factors that could improve access to care. |  From a tooth-on-a-chip to a salivary gland chip and more, scientists are developing microchips that mimic parts of our mouths to better treat oral diseases. These NIDCR-supported studies are testing dental materials, repurposing drugs for salivary gland dysfunction in head and neck cancer patients, peering into the inner workings of the oral cavity, and opening doors to personalized medicine. |  A recent study, funded in part by NIDCR, found that people who used electronic cigarettes—also called vaping—had unique oral microbial communities that more closely resembled those of smokers than of nonsmokers. These findings may signal an increased risk of gum disease for e-cigarettes users. | Back to top University of Pennsylvania - April 27, 2022 The Scripps Research Institute - April 12, 2022 University of Pittsburgh - April 11, 2022 University at Buffalo - April 7, 2022 Clemson University - March 7, 2022 New York University - February 22, 2022 Back to top - Harnessing Data Science for Health Discovery and Innovation in Africa (DS-I Africa): Research Education Program (UE5 Clinical Trial Not Allowed)
Expiration Date: 09/29/2022 - Harnessing Data Science for Health Discovery and Innovation in Africa (DS-I Africa): Partnership for Innovation Research Projects (U01 Clinical Trial Not Allowed)
Expiration Date: 12/07/2022 - Notice of Special Interest (NOSI): Increasing Uptake of Evidence-Based Screening in Diverse Populations Across the Lifespan
Expiration Date: 05/08/2025 - Notice of Special Interest (NOSI): Addressing Evidence Gaps in Screening
Expiration Date: 05/08/2025 - Notice of Change to PAR-20-238, "Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)"
Expiration Date: 01/01/2025 - HEAL Initiative: Team Research for Initial Translational Efforts in Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed)
Expiration Date: 10/11/2023 - Fogarty HIV Research Training Program for Low-and Middle-Income Country Institutions (D43 Clinical Trial Optional)
Expiration Date: 08/23/2024 - Planning Grant for Fogarty HIV Research Training Program for Low- and Middle-Income Country Institutions (D71 Clinical Trial Not Allowed)
Expiration Date: 08/23/2024 - Infrastructure Development Training Programs for Critical HIV Research at Low-and Middle-Income Country Institutions (G11 Clinical Trials Not Allowed)
Expiration Date: 08/23/2024 - Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)
Expiration Date: 07/16/2022 - NIH Director's Pioneer Award Program (DP1 Clinical Trial Optional)
Expiration Date: 09/10/2022 - Technologies and Assays for Therapeutic Genome Editing INDs (U01, Clinical Trial Not Allowed)
Expiration Date: 07/20/2022 - IND-enabling Studies of Somatic Genome Editing Therapeutic Leads (U19, Clinical Trial Not allowed)
Expiration Date: 07/20/2022 - Platform Clinical Trials of Genome Editors in Multiple Diseases (UG3/UH3, Clinical Trial Required)
Expiration Date: 07/20/2022 - Somatic Cell Genome Editing Program Translational Coordination and Dissemination Center (TCDC) (U24 - Clinical Trial Not Allowed)
Expiration Date: 07/20/2022 - NIH Director's New Innovator Award Program (DP2 Clinical Trial Optional)
Expiration Date: 08/20/2022 - Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed)
Expiration Date: 07/02/2024 - Chronic, Non-Communicable Diseases and Disorders Across the Lifespan: Fogarty International Research Training Award (NCD-LIFESPAN) (D43 Clinical Trial Optional)
Expiration Date: 07/16/2024 - Somatic Mosaicism across Human Tissues (SMaHT) Program: Organizational Center (U24 Clinical Trial Not Allowed)
Expiration Date: 07/09/2022 - Somatic Mosaicism across Human Tissues (SMaHT) Program: Data Analysis Center (UM1 Clinical Trial Not Allowed)
Expiration Date: 07/09/2022 - Somatic Mosaicism across Human Tissues (SMaHT) Program: Tool Development Projects (UG3/UH3 Clinical Trial Not Allowed)
Expiration Date: 07/09/2022 - Somatic Mosaicism across Human Tissues (SMaHT) Program: Tissue Procurement Center (U24 Clinical Trial Not Allowed)
Expiration Date: 07/09/2022 - Somatic Mosaicism across Human Tissues (SMaHT) Program: Genome Characterization Centers (UM1 Clinical Trial Not Allowed)
Expiration Date: 07/09/2022 - Notice of Intent to Publish a Funding Opportunity Announcement for Data-Driven Tools to Accelerate the Clinical Translation of Novel Dental, Oral, and Craniofacial Biomaterials (R61/R33 Clinical Trial Not Allowed)
Expiration Date: 07/15/2022 - Notice of Intent to Publish a Funding Opportunity Announcement for Data-Driven Tools to Accelerate the Clinical Translation of Novel Dental, Oral, and Craniofacial Biomaterials (Fast-Track R42 Clinical Trial Not Allowed)
Expiration Date: 07/15/2022 - Notice of Intent to Publish a Funding Opportunity Announcement for Data-Driven Tools to Accelerate the Clinical Translation of Novel Dental, Oral, and Craniofacial Biomaterials (Fast-Track - R44 Clinical Trial Not Allowed)
Expiration Date: 07/15/2022 - Notice of Special Interest (NOSI): Administrative Supplement for Research Efforts that Illuminate Fundamental Processes Underlying Behavior Change, Maintenance, and Adherence (Admin Supp Clinical Trial Optional)
Expiration Date: 07/16/2022 - Notice of Special Interest (NOSI): NIH Research Project Grants on Down Syndrome (R01) for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project
Expiration Date: 05/01/2025 - Notice of Special Interest (NOSI): Mentored Career Development Awards to Foster the Careers of Investigators Pursuing Research Related to Down syndrome as Part of the INCLUDE Project
Expiration Date: 11/13/2024 - NIH Director's Transformative Research Awards (R01 Clinical Trial Optional)
Expiration Date: 09/02/2022 - Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)
Expiration Date: 05/08/2025 - Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed)
Expiration Date: 09/08/2025 - Short-term Mentored Career Enhancement Award in Dental, Oral, and Craniofacial Research for Mid-Career and Senior Investigators (K18- Independent Clinical Trial Not Allowed)
Expiration Date: 05/08/2025 - NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03 Clinical Trial Not Allowed)
Expiration Date: 05/08/2025 - Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional)
Expiration Date: 10/18/2024 - Notice of Intent to Publish a Funding Opportunity Announcement for NIDCR Small Research Grants for Oral Health Data Analysis and Statistical Methodology Development (R03 Clinical Trial Not Allowed)
Expiration Date: 01/01/2025 - Notice of Participation of Additional NIH Institutes and Centers in PAR-20-153: Science Education Partnership Awards (SEPA) (R25-Clinical Trial Not Allowed)
Expiration Date: 01/01/2025 - Notice of Special Interest (NOSI): Administrative Supplements for Research on Womens Health in the IDeA States
Expiration Date: 10/18/2024 - Notice to Include Additional Application Due Dates for NIDCR Dual Degree Dentist Scientist Pathway to Independence Award (K99/R00)
Expiration Date: 01/01/2025 - Notice of Special Interest: NIDCR Administrative Supplements to NCATS CTSA Programs for Scholars Pursuing Dental, Oral, and Craniofacial Clinical and Translational Research Career Development
Expiration Date: 09/16/2022 - Notice of Change to Correct Eligibility Information under RFA-RM-22-008; "NIH Faculty Institutional Recruitment for Sustainable Transformation (FIRST) Program: FIRST Cohort (U54 Clinical Trial Optional)"
Expiration Date: 07/13/2022 - NIDCR Notice of Participation in PAR-20-076, "Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program in the Neurosciences (T32 Clinical Trial Not Allowed)"
Expiration Date: 01/01/2025 Back to top Visit the NIDCR website to sign up for NIDCR News. Back to top |
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