About the Webinar Within-subject clinical trials have long been considered an inferior option to randomized clinical trials in psychology and medicine even though they can address critical research questions that randomized trials cannot. Coupling within-subject experimental designs with rigorous statistical analysis, referred to as idiographic clinical trials, overcomes many historical limitations of within-subject designs. This has led to recent fundamental advances and spurred a resurgence in using these methods. This presentation will briefly review idiographic clinical trials, their strengths and limitations, and recent advances in these methodologies. Finally, the newly developed PersonAlyticsPower R package for a priori power analyses to plan study designs will be presented. PersonAlyticsPower will be illustrated with results from a recent series of Monte Carlo simulations which explored the impact of multiple study design factors on statistical power to detect treatment effects such as sample size, number of repeated observations, and number of observations per study phase. The motivating contexts and examples to illustrate idiographic clinical trials will be prevention science and treatments for rare diseases. General recommendations for designing idiographic clinical trials will be drawn from the Monte Carlo simulations. This research was supported by funding from the National Center for Advancing Translational Sciences (R21TR002402, principal investigator Ridenour). About Ty Ridenour  Dr. Ty Ridenour is a Senior Developmental Behavioral Epidemiologist in the Center on Social Determinants, Risk Behaviors, and Prevention Science at RTI International. Dr. Ridenour has collaborated on idiographic clinical trials research for over 15 years in a range of fields including prevention science, endocrinology, intimate partner violence, psychotherapy, physical rehabilitation, and wearable biosensors. | About Stephen Tueller  Dr. Stephen Tueller is a Senior Research Statistician in the Division of Applied Justice Research at RTI International. Dr. Tueller provides design and analysis leadership for several ongoing multisite randomized trials, hybrid trials, idiographic clinical trials, and implementation studies in research areas spanning child welfare, juvenile justice, human trafficking, rare diseases, HIV services, adult criminal justice, and addiction. | Can't be there? A recording of this webinar will be available approximately 2 weeks after the session. You can view the full archive of previous Methods: Mind the Gap webinars on the Office of Disease Prevention website. This event is open to the public and there will be an opportunity to ask questions at the end of the presentation. Please feel free to share this information widely. This webinar will be captioned in real-time. Individuals needing reasonable accommodations should contact MindtheGap@od.nih.gov. Requests should be made at least 5 business days before the event. |
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